Breast imaging | Acad Radiol 2019 · Co-author; model developer
Breast cancer risk from the mammogram itself
- Clinical problem
- Breast density is a coarse risk marker. The question was whether a network reading the whole mammogram could stratify future risk better.
- My contribution
- I wrote the source code and programmed the CNN risk model, working in Columbia’s breast imaging AI group with Ha (first author) and Jambawalikar (senior author). This line of work led to my NIH StARR-funded CAPRI resident research year.
- Approach
- Retrospective case-control study: prior mammograms of 210 women who later developed cancer (420 images) vs. 527 controls (1,054 images). A fully convolutional network produced a pixel-wise risk map, with an 80/20 split and five-fold cross-validation.
- Published finding
- The network score and breast density were independent predictors. The network’s odds ratio was 4.42 (95% CI 3.4–5.7) vs. 1.67 (1.4–1.9) for density, with 72% accuracy in identifying the case group.
- Limitation
- Single institution, retrospective and relatively small. The authors expected more data to improve the model. A research model.